Why in some cases exercises do not work?


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Why in some cases exercises do not work?

Regular physical activities are considered as an essential element, supporting the prevention of obesity and related to extracurricular pounds health conditions. As it turns out, some of us derive much greater benefit from regular exercises than others. Recent studies seem to know the answer to the question why is this happening.

According to recent findings based on research in both mice and humans, higher levels of selenoprotein P – the protein secreted by the liver, might cause the less dynamic exercise effects and, consequently, limited benefits associated with the regular physical activity.

These studies were conducted by researchers from the Canadian College of Medical Sciences, Kanazawa.

Studies suggest that selenoprotein P can cause resistance to physical effort.

Current guidelines recommend that adults should practice an average of about 150 minutes deciding on the aerobic activity of moderate intensity or 75 minutes of intense activity a week because this amount will allow remaining healthy.

However, depending on the person, the response to exercise – both regarding strength and metabolic health, may be entirely different. Some people do not feel any results despite regular aerobic exercise. Similar relationships show that 15-20 percent of individuals who have type 2 diabetes, where, despite performing a routine physical activity, hypoglycemia does not show appropriate changes.

Recent discoveries show that some of us suffer from resistance to exercise, and therefore have limited opportunities to benefit from the regular physical activity.

The precise mechanisms of resistance on exercises have not been clear, but recent studies indicate that selenoprotein P may play a significant role in this relationship, which is why scientists from the Canadian College of Medical Sciences, Kanazawa undertook further study of this compound.

During the tests, the team assessed the effects of physical exercise on two groups of mice – some of them had a deficiency in selenoprotein P, and the other part of them was a randomized control group. Both groups ran on the treadmill for 30 minutes a day for one month. Researchers have found that those of the mice that were free of selenoprotein P had double exercise capacity as those in compared control group.

Interestingly, the mice exhibiting a limited amount of selenoprotein P at the end of the month-long test had reduced the blood glucose level after the injection of the insulin hormone.

It should also be noted that the control group of mice before the month of treadmill training, received an additional dose of selenoprotein P. Rodents in this group have shown, among other things, a reduction in the AMPK enzyme phosphorylation in muscle tissue, and as the scientists explain – AMPK phosphorylation is strongly linked to the many benefits that regular exercises can give to us.

Besides, the researchers showed that mice lacking LRP1 – selenoprotein P receptor in muscle, could not absorb the selenoprotein P into the muscles, and phosphorylation of AMPK hasn’t got any influence on their effectiveness on the exercise.

Conclusions from the study may support the discovery of medicines that stimulate the benefits of exercise.

A team of researchers from the Canadian College of Medical Sciences in Kanazawa took up further studies to demonstrate how the selenoprotein P may affect the effectiveness of exercise in humans.


Therefore, 31 healthy women who did not train regularly were subjected to the study. All women participated in aerobic training during the eight-week period, and their maximum oxygen uptake during exercise was monitored throughout the period to determine their exercise tolerance during exercise.

The team found that women with high levels of selenoprotein P in the blood before the start of the 8-week study showed lower maximal oxygen intake compared to those with lower levels of selenoprotein P. Researchers believe that this liver-induced protein promotes exercise by targeting the LRP1 receptor on the muscles.

Further studies are needed to obtain more detailed information on the effects of selenoprotein P on physical activity, but the team agrees that this study may pave the way for the development of medications that will help to reduce the production of selenoprotein P to increase exercise endurance.

So far, the present findings suggest that future screening for inhibitors axis (selenoprotein P) – LRP1 can help develop stimulant medication effort to treat diseases associated with a lack of physical activity, such as type 2 diabetes.

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