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The genes responsible for male baldness discovered
Male baldness is quite a common problem that can have adverse psychological effects, and some research indicates its relationship with some serious diseases. According to recent discoveries, scientists have detected several genetic variants that are associated with this unpleasant condition. This news may ultimately allow researchers to predict the problem of excessive hair loss and also help search the methods of preventive.
Male pattern baldness is also referred to as androgenetic alopecia or MPB, and it affects in varying degrees up to 95% of men. Most cases of intensive hair loss – up to 80%, affects people around the fifty years of age. Unfortunately, male baldness also affects men under the age of 35, which is for many of them the far-reaching problem.
Many of the men suffering from baldness experience numerous negative effects, such as difficulty accepting themselves, as well as problems in relationships. Some clinical trials have shown a link between the male baldness and major diseases such as prostate cancer and cardiovascular disease.
The new study found more than 280 genetic variants that are responsible for male pattern baldness.
A new survey conducted by Saskia Hagenaars and David Hill of the University of Edinburgh in the United Kingdom have discovered a genetic basis of the disease which is baldness. Analysis of genomics and health of more than 52,000 men showed more than 280 autonomous genetic regions associated with severe hair loss.
Researchers divided 52,000 participants into two groups, one of which was the 40000, and the second – 12000 which is a target group. Based on the genetic variants, the men were divided into those who do not lose their hair, as well as those characterized by a severe degree of baldness. A team of researchers based on data developed an algorithm, the purpose of which was to enable to predict that with whom will be revealed a problem with hair loss.
The algorithmic method of determining forecasts of baldness is based on the results of genetic tests, and although its full potential still requires sizeable effort. The results of the discovery may soon allow for the identification of population groups that are at increased risk of hair loss.
In between the examined participants, the researchers found that 16700 does not have any problems with hair loss, 12000 has a little problem with alopecia, 14000 suffer from a moderate form of hair loss, and the 9800 has a serious issue. The researchers linked the genetic patterns of each of participating in the trials men with the degree of hair loss. Those who performed less than half of the genes associated with hair loss had reduced the risk of becoming bald. Only 14% of participants in this group were bald, and 39% did not lose any hair. In 58% of the total observed some signs of hair loss.
The newly discovered genetic signals (exactly 287), which have been identified by scientists proved to be fascinating. Many genetic signals (as determined from the tests, even about 40) which were combined with alopecia in men are related to X-chromosome, which they inherit from their mothers. The rest are scattered throughout the genome.
It should be noted, however, that these studies collect data on the pattern of baldness, so they do not tell us at what age baldness may occur. It should be expected some stronger genetic signals in individuals who belong to the group of early onset of baldness. As the authors of the study say, it is the biggest and the most actual, with so far made on the subject of problems of hair loss in men. To the discovery of the most efficient methods of forecasting disease entity of baldness, we still have a long way to go, but the test results seem to be a big step forward. They allow paving the way for a better understanding of the causes of hair loss. Let’s hope that very soon, a simple blood test will help to determine information about whether and when they may appear the problem of baldness.Don't miss another post: